Echinococcosis, Ningxia, China
نویسندگان
چکیده
demonstrated enhanced entry into renal epithelial cells (10). In our studies, we did not find enhanced virus replication in the respiratory tract of vaccinated mice upon SARS-CoV challenge. However, since mice are a model of SARS-CoV infection but not disease, the issue of disease enhancement will have to be carefully evaluated if and when an appropriate animal model in which this phenomenon can be demonstrated becomes available. In summary, an inactivated SARSCoV vaccine, produced with a technology that has a safety record established by immunizing hundreds of millions of persons, protects mice from challenge with SARS-CoV. The vaccine adjuvanted with MF59 elicits neutralizing antibodies (titer 1:91) after only 2 doses. We conclude that the vaccine described here has desirable properties, and our data support further development and plans for clinical trials.
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Yu Rong Yang,*† Tao Sun,† Zhengzhi Li,† Xiuping Li,† Rui Zhao,† Li Cheng,‡ Xiao Pan,§ Philip S. Craig,¶ Dominique A. Vuitton,# and Donald P. McManus* *Queensland Institute of Medical Research, Brisbane, Queensland, Australia; †Ningxia Medical College, Ningxia Hui Autonomous Region, China; ‡The Second Provincial Hospital of Ningxia Hui Autonomous Region, Ningxia, China; § Xiji County Hospital, X...
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